5YZC

Crystal structure of the prefusion form of measles virus fusion protein in complex with a fusion inhibitor compound (AS-48)

Summary for 5YZC

• Entry DOI: 10.2210/pdb5yzc/pdb
• Related: 5YXW
• Descriptor: glycoprotein F2, glycoprotein F1,measles virus fusion protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: glycoprotein, viral protein, fusion protein, paramyxovirus, inhibitor, chemical compound
• Biological source: Measles virus (strain Ichinose-B95a) (MeV); More
• Cellular location: Virion membrane ; Single-pass type I membrane protein : Q786F3
• Total number of polymer chains: 2
• Total formula weight: 56395.10

Authors

Hashiguchi, T.,Fukuda, Y.,Matsuoka, R.,Kuroda, D.,Kubota, M.,Shirogane, Y.,Watanabe, S.,Tsumoto, K.,Kohda, D.,Plemper, R.K.,Yanagi, Y. (deposition date: 2017-12-14, release date: 2018-02-21, Last modification date: 2023-11-22)

• Primary citation: Hashiguchi, T.,Fukuda, Y.,Matsuoka, R.,Kuroda, D.,Kubota, M.,Shirogane, Y.,Watanabe, S.,Tsumoto, K.,Kohda, D.,Plemper, R.K.,Yanagi, Y.; Structures of the prefusion form of measles virus fusion protein in complex with inhibitors.; Proc. Natl. Acad. Sci. U.S.A., 115:2496-2501, 2018; PubMed: 29463726; DOI: 10.1073/pnas.1718957115

Experimental method

X-RAY DIFFRACTION (2.334 Å)