5YYF
Crystal structure of AF9 YEATS domain in complex with a peptide inhibitor "PHQ-H3(Q5-K9)" modified at K9 with 2-furancarboyl group
Summary for 5YYF
Entry DOI | 10.2210/pdb5yyf/pdb |
Related PRD ID | PRD_002284 |
Descriptor | Protein AF-9, Peptide inhibitor PHQ-H3(Q5-K9), SULFATE ION, ... (5 entities in total) |
Functional Keywords | yeats domain, complex, inhibitor, 2-furancarboyl group, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 35245.24 |
Authors | |
Primary citation | Li, X.,Li, X.M.,Jiang, Y.,Liu, Z.,Cui, Y.,Fung, K.Y.,van der Beelen, S.H.E.,Tian, G.,Wan, L.,Shi, X.,Allis, C.D.,Li, H.,Li, Y.,Li, X.D. Structure-guided development of YEATS domain inhibitors by targeting pi-pi-pi stacking. Nat. Chem. Biol., 14:1140-1149, 2018 Cited by PubMed: 30374167DOI: 10.1038/s41589-018-0144-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.903 Å) |
Structure validation
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