5YW4
Structure-Guided Engineering of Reductase: Efficient Attenuating Substrate Inhibition in Asymmetric Catalysis
Summary for 5YW4
Entry DOI | 10.2210/pdb5yw4/pdb |
Descriptor | Protein induced by osmotic stress, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total) |
Functional Keywords | reductase, nadp+, asymmetric catalysis, oxidoreductase |
Biological source | Scheffersomyces stipitis (Yeast) |
Total number of polymer chains | 1 |
Total formula weight | 37749.27 |
Authors | Shang, Y.P.,Chen, Q.,Li, A.T.,Yu, H.L.,Xu, J.H. (deposition date: 2017-11-28, release date: 2019-03-06, Last modification date: 2023-11-22) |
Primary citation | Shang, Y.P.,Chen, Q.,Li, A.T.,Quan, S.,Xu, J.H.,Yu, H.L. Attenuated substrate inhibition of a haloketone reductase via structure-guided loop engineering. J.Biotechnol., 308:141-147, 2020 Cited by PubMed: 31866427DOI: 10.1016/j.jbiotec.2019.12.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.047 Å) |
Structure validation
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