5YOK
Structure of HIV-1 Protease in Complex with Inhibitor KNI-1657
Summary for 5YOK
Entry DOI | 10.2210/pdb5yok/pdb |
Descriptor | HIV-1 PROTEASE, (4R)-N-[(2,6-dimethylphenyl)methyl]-3-[(2S,3S)-3-[[(2S)-2-[(7-methoxy-1-benzofuran-2-yl)carbonylamino]-2-[(3R)-oxolan-3 -yl]ethanoyl]amino]-2-oxidanyl-4-phenyl-butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22684.84 |
Authors | Adachi, M.,Hidaka, K.,Kuroki, R.,Kiso, Y. (deposition date: 2017-10-29, release date: 2018-07-18, Last modification date: 2024-03-27) |
Primary citation | Hidaka, K.,Kimura, T.,Sankaranarayanan, R.,Wang, J.,McDaniel, K.F.,Kempf, D.J.,Kameoka, M.,Adachi, M.,Kuroki, R.,Nguyen, J.T.,Hayashi, Y.,Kiso, Y. Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine. J. Med. Chem., 61:5138-5153, 2018 Cited by PubMed: 29852069DOI: 10.1021/acs.jmedchem.7b01709 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.85 Å) |
Structure validation
Download full validation report