Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 44 |
| Details | binding site for residue 8Z0 A 101 |
| Chain | Residue |
| A | TRP6 |
| A | GLY49 |
| A | ILE50 |
| A | PRO81 |
| A | VAL82 |
| A | ILE84 |
| A | HOH202 |
| A | HOH207 |
| A | HOH212 |
| A | HOH220 |
| A | HOH247 |
| A | ARG8 |
| A | HOH248 |
| A | HOH282 |
| A | HOH288 |
| A | HOH308 |
| A | HOH367 |
| A | HOH442 |
| A | HOH499 |
| B | ARG8 |
| B | LEU23 |
| B | ASP25 |
| A | LEU23 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | ASP30 |
| B | VAL32 |
| B | GLY48 |
| B | GLY49 |
| B | ILE50 |
| B | PRO81 |
| B | VAL82 |
| A | ASP25 |
| B | ILE84 |
| B | HOH210 |
| B | HOH354 |
| B | HOH399 |
| B | HOH429 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | GLY48 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue GOL B 101 |
| Chain | Residue |
| A | GLN18 |
| A | MET36 |
| A | SER37 |
| B | THR12 |
| B | ILE13 |
| B | LYS14 |
| B | LEU19 |
| B | GLU65 |
| B | ALA67 |
| B | GLY68 |
| B | HOH232 |
| B | HOH260 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 102 |
| Chain | Residue |
| A | HOH407 |
| B | GLU35 |
| B | LYS55 |
| B | ARG57 |
| B | VAL77 |
| B | GLY78 |
| B | HOH206 |
| B | HOH278 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
