5YJM
Human chymase in complex with 7-oxo-3-(phenoxyimino)-1,4-diazepane derivative
Summary for 5YJM
Entry DOI | 10.2210/pdb5yjm/pdb |
Descriptor | human chymase, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total) |
Functional Keywords | protease, inhibitor, complex, hydrolase |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 26134.79 |
Authors | Sugawara, H. (deposition date: 2017-10-11, release date: 2017-12-27, Last modification date: 2020-07-29) |
Primary citation | Futamura-Takahashi, J.,Tanaka, T.,Sugawara, H.,Iwashita, S.,Imajo, S.,Oyama, Y.,Muto, T. Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors Bioorg. Med. Chem. Lett., 28:188-192, 2018 Cited by PubMed: 29191554DOI: 10.1016/j.bmcl.2017.11.031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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