5YJF

Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with small molecule analog of Nicotinamide

Summary for 5YJF

Entry DOI	10.2210/pdb5yjf/pdb
Descriptor	Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 6-methoxy-1-methyl-2H-pyridine-3-carboxamide, ... (4 entities in total)
Functional Keywords	nnmt, na, mna, t2d, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P40261
Total number of polymer chains	4
Total formula weight	128627.15
Authors	Swaminathan, S.,Birudukota, S.,Thakur, M.K.,Parveen, R.,Kandan, S.,Hallur, M.S.,Rajagopal, S.,Ruf, S.,Dhakshinamoorthy, S.,Kannt, A.,Gosu, R. (deposition date: 2017-10-10, release date: 2018-03-21, Last modification date: 2023-11-22)
Primary citation	Kannt, A.,Rajagopal, S.,Kadnur, S.V.,Suresh, J.,Bhamidipati, R.K.,Swaminathan, S.,Hallur, M.S.,Kristam, R.,Elvert, R.,Czech, J.,Pfenninger, A.,Rudolph, C.,Schreuder, H.,Chandrasekar, D.V.,Mane, V.S.,Birudukota, S.,Shaik, S.,Zope, B.R.,Burri, R.R.,Anand, N.N.,Thakur, M.K.,Singh, M.,Parveen, R.,Kandan, S.,Mullangi, R.,Yura, T.,Gosu, R.,Ruf, S.,Dhakshinamoorthy, S. A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep, 8:3660-3660, 2018 Cited by PubMed: 29483571 DOI: 10.1038/s41598-018-22081-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation