5YJF
Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with small molecule analog of Nicotinamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Nicotinamide N-methyltransferase | polymer | 284 | 31604.2 | 4 | UniProt (P40261) Pfam (PF01234) In PDB | Homo sapiens (Human) | |
2 | A, B, C, D | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) | |||
3 | A, B, C, D | 6-methoxy-1-methyl-2H-pyridine-3-carboxamide | non-polymer | 168.2 | 4 | Chemie (8WO) | |||
4 | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 264 (UniProt: P40261)
PDB | External Database | Details |
---|---|---|
Met -19 | - | expression tag |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Ala 100 | Lys 100 | engineered mutation |
Ala 101 | Glu 101 | engineered mutation |
Ala 103 | Glu 103 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 126416.7 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2210.4 | |
All* | Total formula weight | 128627.2 |