5YBF

Crystal structure of the GluA2o LBD in complex with glutamate and HBT1

5YBF の概要

• エントリーDOI: 10.2210/pdb5ybf/pdb
• 分子名称: Glutamate receptor 2,Glutamate receptor 2, GLUTAMIC ACID, 2-[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanoylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, ... (6 entities in total)
• 機能のキーワード: ampa receptor ligand-binding domain, allosteric modulation complex, membrane protein, transport protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein : P42262
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 178841.11

構造登録者

Sogabe, S.,Igaki, S.,Hirokawa, A.,Zama, Y.,Lane, W.,Snell, G. (登録日: 2017-09-04, 公開日: 2018-01-17, 最終更新日: 2023-11-22)

• 主引用文献: Kunugi, A.,Tajima, Y.,Kuno, H.,Sogabe, S.,Kimura, H.; HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production.; J. Pharmacol. Exp. Ther., 364:377-389, 2018; PubMed: 29298820; DOI: 10.1124/jpet.117.245050

実験手法

X-RAY DIFFRACTION (1.5 Å)