5Y7N

Crystal structure of AKR1B10 in complex with NADP+ and Androst-4-ene-3-beta-6-alpha-diol

Summary for 5Y7N

• Entry DOI: 10.2210/pdb5y7n/pdb
• Descriptor: Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (3S,6S,8S,9S,10R,13S,14R)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol, ... (4 entities in total)
• Functional Keywords: akr1b10, steroid, complex, inhibitor, antitumor protein, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 37105.39

Authors

Hong, Z.,Liping, Z.,Cuiyun, L.,Wei, Z. (deposition date: 2017-08-17, release date: 2018-08-29, Last modification date: 2023-11-22)

• Primary citation: Hong, Z.,Cuiyun, L.; Structural determinants for the inhibition of AKR1B10 by steroids; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)