5Y4P
Crystal structure of Trypanosoma cruzi spermidine synthase in complex with 5-methoxy-2-(5-methyl-4,5-dihydro-1H-imidazol-2-yl)phenol
Summary for 5Y4P
Entry DOI | 10.2210/pdb5y4p/pdb |
Descriptor | Spermidine synthase, putative, 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, 5-methoxy-2-[(5R)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]phenol, ... (4 entities in total) |
Functional Keywords | polyamine synthesis, transferase |
Biological source | Trypanosoma cruzi (strain CL Brener) |
Total number of polymer chains | 4 |
Total formula weight | 138665.63 |
Authors | Amano, Y.,Tateishi, Y. (deposition date: 2017-08-04, release date: 2018-08-08, Last modification date: 2023-12-06) |
Primary citation | Yoshino, R.,Yasuo, N.,Hagiwara, Y.,Ishida, T.,Inaoka, D.K.,Amano, Y.,Tateishi, Y.,Ohno, K.,Namatame, I.,Niimi, T.,Orita, M.,Kita, K.,Akiyama, Y.,Sekijima, M. Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro , and X-ray Crystallography. Acs Omega, 8:25850-25860, 2023 Cited by PubMed: 37521650DOI: 10.1021/acsomega.3c01314 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.16 Å) |
Structure validation
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