5Y4H
Human SIRT3 in complex with halistanol sulfate
Summary for 5Y4H
Entry DOI | 10.2210/pdb5y4h/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-3, mitochondrial, THr-Arg-Ser-GLY-ALY-VAL-MET-ARG-ARG-LEU-ARG-ARG, ZINC ION, ... (5 entities in total) |
Functional Keywords | sirtuin, nad-dependent deacetylase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Mitochondrion matrix : Q9NTG7 |
Total number of polymer chains | 2 |
Total formula weight | 33915.55 |
Authors | Kudo, N.,Ito, A.,Yoshida, M. (deposition date: 2017-08-03, release date: 2018-05-16, Last modification date: 2023-11-22) |
Primary citation | Nakamura, F.,Kudo, N.,Tomachi, Y.,Nakata, A.,Takemoto, M.,Ito, A.,Tabei, H.,Arai, D.,de Voogd, N.,Yoshida, M.,Nakao, Y.,Fusetani, N. Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria J. Antibiot., 71:273-278, 2018 Cited by PubMed: 29184120DOI: 10.1038/ja.2017.145 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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