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5Y4H

Human SIRT3 in complex with halistanol sulfate

Summary for 5Y4H
Entry DOI10.2210/pdb5y4h/pdb
DescriptorNAD-dependent protein deacetylase sirtuin-3, mitochondrial, THr-Arg-Ser-GLY-ALY-VAL-MET-ARG-ARG-LEU-ARG-ARG, ZINC ION, ... (5 entities in total)
Functional Keywordssirtuin, nad-dependent deacetylase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological sourceHomo sapiens (Human)
More
Cellular locationMitochondrion matrix : Q9NTG7
Total number of polymer chains2
Total formula weight33915.55
Authors
Kudo, N.,Ito, A.,Yoshida, M. (deposition date: 2017-08-03, release date: 2018-05-16, Last modification date: 2023-11-22)
Primary citationNakamura, F.,Kudo, N.,Tomachi, Y.,Nakata, A.,Takemoto, M.,Ito, A.,Tabei, H.,Arai, D.,de Voogd, N.,Yoshida, M.,Nakao, Y.,Fusetani, N.
Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria
J. Antibiot., 71:273-278, 2018
Cited by
PubMed: 29184120
DOI: 10.1038/ja.2017.145
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

건을2024-03-27부터공개중

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