5Y25
EGFR kinase domain mutant (T790M/L858R) with covalent ligand NS-062
Summary for 5Y25
Entry DOI | 10.2210/pdb5y25/pdb |
Descriptor | Epidermal growth factor receptor, (2R)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide (2 entities in total) |
Functional Keywords | inhibitor, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 38741.19 |
Authors | Shiroishi, M.,Abe, Y.,Caaveiro, J.M.M.,Sakamoto, S.,Morimoto, S.,Fuchida, H.,Shindo, N.,Ojida, A. (deposition date: 2017-07-24, release date: 2018-07-25, Last modification date: 2023-11-22) |
Primary citation | Shindo, N.,Fuchida, H.,Sato, M.,Watari, K.,Shibata, T.,Kuwata, K.,Miura, C.,Okamoto, K.,Hatsuyama, Y.,Tokunaga, K.,Sakamoto, S.,Morimoto, S.,Abe, Y.,Shiroishi, M.,Caaveiro, J.M.M.,Ueda, T.,Tamura, T.,Matsunaga, N.,Nakao, T.,Koyanagi, S.,Ohdo, S.,Yamaguchi, Y.,Hamachi, I.,Ono, M.,Ojida, A. Selective and reversible modification of kinase cysteines with chlorofluoroacetamides. Nat.Chem.Biol., 15:250-258, 2019 Cited by PubMed: 30643284DOI: 10.1038/s41589-018-0204-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.102 Å) |
Structure validation
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