5Y25

EGFR kinase domain mutant (T790M/L858R) with covalent ligand NS-062

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Epidermal growth factor receptor	polymer	332	38152.2	1	UniProt (P00533) Pfam (PF07714) In PDB	Homo sapiens (Human)	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
2	A	(2R)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide	non-polymer		589.0	1	Chemie (8LU)

Sequence modifications

A: 698 - 1022 (UniProt: P00533)

PDB	External Database	Details
Met 691	-	expression tag
His 692	-	expression tag
His 693	-	expression tag
His 694	-	expression tag
His 695	-	expression tag
His 696	-	expression tag
His 697	-	expression tag
Met 790	Thr 790	engineered mutation
Arg 858	Leu 858	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38152.2
Non-Polymers*	Number of molecules	1
	Total formula weight	589.0
All*	Total formula weight	38741.2

*Water molecules are not included.