5Y25
EGFR kinase domain mutant (T790M/L858R) with covalent ligand NS-062
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 332 | 38152.2 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A | (2R)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide | non-polymer | 589.0 | 1 | Chemie (8LU) |
Sequence modifications
A: 698 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Met 691 | - | expression tag |
His 692 | - | expression tag |
His 693 | - | expression tag |
His 694 | - | expression tag |
His 695 | - | expression tag |
His 696 | - | expression tag |
His 697 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Arg 858 | Leu 858 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 38152.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 589.0 | |
All* | Total formula weight | 38741.2 |