5XTW

Crystal structure of the CysR-CTLD2 fragment of human MR at acidic pH

Summary for 5XTW

• Entry DOI: 10.2210/pdb5xtw/pdb
• Descriptor: Macrophage mannose receptor 1, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION (3 entities in total)
• Functional Keywords: collagen binding, lectin-activity, endocytic receptor, immune receptor, sugar binding protein
• Biological source: Homo sapiens (Human)
• Cellular location: Endosome membrane ; Single-pass type I membrane protein : P22897
• Total number of polymer chains: 8
• Total formula weight: 437105.68

Authors

He, Y.,Hu, Z. (deposition date: 2017-06-21, release date: 2017-12-27, Last modification date: 2023-11-22)

• Primary citation: Hu, Z.,Shi, X.,Yu, B.,Li, N.,Huang, Y.,He, Y.; Structural Insights into the pH-Dependent Conformational Change and Collagen Recognition of the Human Mannose Receptor; Structure, 26:60-71.e3, 2018; PubMed: 29225077; DOI: 10.1016/j.str.2017.11.006

Experimental method

X-RAY DIFFRACTION (3.2 Å)