5XTW

Crystal structure of the CysR-CTLD2 fragment of human MR at acidic pH

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MES A 501

Chain	Residue
A	ASN118
A	ASN121
A	GLY132
A	SER133
A	GLY134
A	LEU135
A	TRP136

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CA A 502

Chain	Residue
A	GLU461
A	ASP475
A	GLU452
A	SER454

---

site_id	AC3
Number of Residues	8
Details	binding site for residue MES B 501

Chain	Residue
B	ASN118
B	ASN121
B	TYR130
B	GLY132
B	SER133
B	GLY134
B	LEU135
B	TRP136

---

site_id	AC4
Number of Residues	8
Details	binding site for residue MES C 501

Chain	Residue
C	ASN118
C	ASN121
C	GLY132
C	SER133
C	GLY134
C	LEU135
C	TRP136
C	SER137

---

site_id	AC5
Number of Residues	4
Details	binding site for residue CA C 502

Chain	Residue
C	GLU452
C	SER454
C	GLU461
C	ASP475

---

site_id	AC6
Number of Residues	8
Details	binding site for residue MES D 501

Chain	Residue
D	ASN118
D	ASN121
D	GLY132
D	SER133
D	GLY134
D	LEU135
D	TRP136
D	SER137

---

site_id	AC7
Number of Residues	4
Details	binding site for residue CA D 502

Chain	Residue
D	GLU452
D	SER454
D	GLU461
D	ASP475

---

site_id	AC8
Number of Residues	6
Details	binding site for residue MES E 501

Chain	Residue
E	ASN118
E	ASN121
E	SER133
E	GLY134
E	TRP136
E	SER137

---

site_id	AC9
Number of Residues	4
Details	binding site for residue CA E 502

Chain	Residue
E	GLU452
E	SER454
E	GLU461
E	ASP475

---

site_id	AD1
Number of Residues	7
Details	binding site for residue MES F 501

Chain	Residue
F	ASN118
F	ASN121
F	GLY132
F	SER133
F	GLY134
F	LEU135
F	TRP136

---

site_id	AD2
Number of Residues	4
Details	binding site for residue CA F 502

Chain	Residue
F	GLU452
F	SER454
F	GLU461
F	ASP475

---

site_id	AD3
Number of Residues	7
Details	binding site for residue MES G 501

Chain	Residue
G	ASN118
G	ASN121
G	GLY132
G	SER133
G	GLY134
G	LEU135
G	TRP136

---

site_id	AD4
Number of Residues	6
Details	binding site for residue MES H 501

Chain	Residue
H	ASN118
H	ASN121
H	TYR130
H	GLY134
H	TRP136
H	SER137

---

site_id	AD5
Number of Residues	4
Details	binding site for residue CA H 502

Chain	Residue
H	GLU452
H	SER454
H	GLU461
H	ASP475

---

Functional Information from PROSITE/UniProt

site_id	PS00615
Number of Residues	25
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CVslnpgknak...WENLECvqklg.YIC

Chain	Residue	Details
A	CYS316-CYS340
A	CYS463-CYS486

---

site_id	PS00023
Number of Residues	42
Details	FN2_1 Fibronectin type-II collagen-binding domain signature. CafPFkFenkwyadCtsagrsdgwlWCgtttDYdtdklFgYC

Chain	Residue	Details
A	CYS168-CYS209

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	384
Details	Domain: {"description":"Fibronectin type-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00479","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	928
Details	Domain: {"description":"C-type lectin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00040","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	590
Details	Domain: {"description":"C-type lectin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00040","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	600
Details	Domain: {"description":"Ricin B-type lectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00174","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---