5XRD

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FS7

Summary for 5XRD

DescriptorHeat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(4-methoxyphenyl)-1H-pyrazol-5-yl}acetamide (3 entities in total)
Functional Keywordsheat shock protein hsp 90, inhibitor, complex, chaperone
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight26038.19
Authors
Li, J.,Shi, F.,Xiong, B.,He, J.H. (deposition date: 2017-06-08, release date: 2019-05-22)
Primary citation
Li, J.,Shi, F.,Xiong, B.,He, J.H.
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FS7
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.18720 0.6% 2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution