5XNW

Crystal structure of ExoY, a unique nucleotidyl cyclase toxin from Pseudomonas aeruginosa

Summary for 5XNW

Entry DOI	10.2210/pdb5xnw/pdb
Descriptor	Adenylate cyclase ExoY, GLYCEROL, SULFATE ION, ... (4 entities in total)
Functional Keywords	nucleotidyl cyclase, virulence effectors, type three secretion system (t3ss), secondary messengers, lyase
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	1
Total formula weight	42067.34
Authors	Khanppnavar, B.,Datta, S. (deposition date: 2017-05-24, release date: 2018-05-30, Last modification date: 2023-11-22)
Primary citation	Khanppnavar, B.,Datta, S. Crystal structure and substrate specificity of ExoY, a unique T3SS mediated secreted nucleotidyl cyclase toxin from Pseudomonas aeruginosa Biochim. Biophys. Acta, 1862:2090-2103, 2018 Cited by PubMed Abstract: The nucleotidyl cyclase toxin ExoY is an important virulence determinant of Pseudomonas aeruginosa that causes severe acute and chronic infections in immune-compromised individuals. Additionally, this unique T3SS effector shows a striking preference for cUMP, a newly identified non-canonical secondary messenger. Thereby, ExoY is also considered as a potential tool to study unexplored cUMP signaling pathways. PubMed: 29859257 DOI: 10.1016/j.bbagen.2018.05.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.201 Å)

Structure validation