5XIG
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 1
Summary for 5XIG
Entry DOI | 10.2210/pdb5xig/pdb |
Related | 5XIF 5XIH 5XII 5XIJ 5XIK 5XIL 5XIO 5XIP 5XIQ |
Descriptor | Prolyl-tRNA synthetase (ProRS), PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | protein translation, prs, synthetase, inhibitor, infectious disease, ligase |
Biological source | Toxoplasma gondii (strain ATCC 50611 / Me49) |
Total number of polymer chains | 4 |
Total formula weight | 235109.62 |
Authors | Jain, V.,Manickam, Y.,Sharma, A. (deposition date: 2017-04-26, release date: 2018-03-07, Last modification date: 2023-11-22) |
Primary citation | Jain, V.,Yogavel, M.,Kikuchi, H.,Oshima, Y.,Hariguchi, N.,Matsumoto, M.,Goel, P.,Touquet, B.,Jumani, R.S.,Tacchini-Cottier, F.,Harlos, K.,Huston, C.D.,Hakimi, M.A.,Sharma, A. Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25:1495-1505.e6, 2017 Cited by PubMed: 28867614DOI: 10.1016/j.str.2017.07.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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