5XIG
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004827 | molecular_function | proline-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004827 | molecular_function | proline-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004827 | molecular_function | proline-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004827 | molecular_function | proline-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006433 | biological_process | prolyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue ANP A 1001 |
| Chain | Residue |
| A | ARG470 |
| A | THR592 |
| A | ARG594 |
| A | MG1002 |
| A | MG1003 |
| A | 87F1004 |
| A | HOH1110 |
| A | HOH1125 |
| A | HOH1131 |
| A | HOH1158 |
| A | HOH1159 |
| A | GLU472 |
| A | HOH1208 |
| A | PHE479 |
| A | LEU480 |
| A | ARG481 |
| A | THR482 |
| A | PHE485 |
| A | TRP487 |
| A | GLN555 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1002 |
| Chain | Residue |
| A | ARG470 |
| A | ANP1001 |
| A | HOH1110 |
| A | HOH1125 |
| A | HOH1159 |
| A | HOH1208 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1003 |
| Chain | Residue |
| A | ANP1001 |
| A | HOH1132 |
| A | HOH1158 |
| A | HOH1223 |
| A | HOH1228 |
| A | HOH1234 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue 87F A 1004 |
| Chain | Residue |
| A | PHE415 |
| A | GLU418 |
| A | THR439 |
| A | GLU441 |
| A | ARG470 |
| A | THR558 |
| A | HIS560 |
| A | TRP589 |
| A | ANP1001 |
| A | HOH1159 |
| A | HOH1213 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue ANP B 1001 |
| Chain | Residue |
| B | ARG470 |
| B | GLU472 |
| B | LYS474 |
| B | PHE479 |
| B | LEU480 |
| B | ARG481 |
| B | THR482 |
| B | PHE485 |
| B | GLN555 |
| B | THR592 |
| B | ARG594 |
| B | MG1002 |
| B | MG1003 |
| B | 87F1004 |
| B | HOH1101 |
| B | HOH1102 |
| B | HOH1116 |
| B | HOH1130 |
| B | HOH1149 |
| B | HOH1160 |
| B | HOH1167 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 1002 |
| Chain | Residue |
| B | ARG470 |
| B | ANP1001 |
| B | HOH1101 |
| B | HOH1102 |
| B | HOH1109 |
| B | HOH1116 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 1003 |
| Chain | Residue |
| B | ANP1001 |
| B | HOH1137 |
| B | HOH1160 |
| B | HOH1167 |
| B | HOH1173 |
| B | HOH1179 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue 87F B 1004 |
| Chain | Residue |
| B | PHE415 |
| B | GLU418 |
| B | THR439 |
| B | GLU441 |
| B | ARG470 |
| B | TRP487 |
| B | THR558 |
| B | HIS560 |
| B | SER588 |
| B | TRP589 |
| B | ANP1001 |
| B | HOH1101 |
| site_id | AC9 |
| Number of Residues | 21 |
| Details | binding site for residue ANP C 1001 |
| Chain | Residue |
| C | MG1003 |
| C | 87F1004 |
| C | HOH1102 |
| C | HOH1115 |
| C | HOH1125 |
| C | HOH1129 |
| C | HOH1135 |
| C | HOH1140 |
| C | HOH1145 |
| C | HOH1147 |
| C | ARG470 |
| C | GLU472 |
| C | PHE479 |
| C | LEU480 |
| C | ARG481 |
| C | THR482 |
| C | PHE485 |
| C | GLN555 |
| C | THR592 |
| C | ARG594 |
| C | MG1002 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 1002 |
| Chain | Residue |
| C | ARG470 |
| C | ANP1001 |
| C | HOH1102 |
| C | HOH1115 |
| C | HOH1135 |
| C | HOH1145 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 1003 |
| Chain | Residue |
| C | ANP1001 |
| C | HOH1140 |
| C | HOH1147 |
| C | HOH1177 |
| C | HOH1178 |
| C | HOH1185 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue 87F C 1004 |
| Chain | Residue |
| C | PHE415 |
| C | GLU418 |
| C | THR439 |
| C | GLU441 |
| C | ARG470 |
| C | THR558 |
| C | HIS560 |
| C | ANP1001 |
| C | HOH1145 |
| site_id | AD4 |
| Number of Residues | 20 |
| Details | binding site for residue ANP D 1001 |
| Chain | Residue |
| D | ARG470 |
| D | GLU472 |
| D | PHE479 |
| D | LEU480 |
| D | ARG481 |
| D | THR482 |
| D | PHE485 |
| D | GLN555 |
| D | THR592 |
| D | ARG594 |
| D | MG1002 |
| D | MG1003 |
| D | 87F1004 |
| D | HOH1105 |
| D | HOH1112 |
| D | HOH1119 |
| D | HOH1131 |
| D | HOH1133 |
| D | HOH1155 |
| D | HOH1165 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 1002 |
| Chain | Residue |
| D | ANP1001 |
| D | HOH1102 |
| D | HOH1120 |
| D | HOH1131 |
| D | HOH1165 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 1003 |
| Chain | Residue |
| D | ANP1001 |
| D | HOH1105 |
| D | HOH1112 |
| D | HOH1139 |
| D | HOH1155 |
| D | HOH1166 |
| site_id | AD7 |
| Number of Residues | 12 |
| Details | binding site for residue 87F D 1004 |
| Chain | Residue |
| D | PHE415 |
| D | GLU418 |
| D | PRO438 |
| D | THR439 |
| D | GLU441 |
| D | ARG470 |
| D | TRP487 |
| D | HIS491 |
| D | THR558 |
| D | HIS560 |
| D | ANP1001 |
| D | HOH1120 |
