5XEB

Structure of the envelope glycoprotein of Dhori virus

Summary for 5XEB

• Entry DOI: 10.2210/pdb5xeb/pdb
• Related: 5XEA
• Descriptor: Envelope glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: dhori virus, glycoprotein, fuion machine, viral protein
• Biological source: Dhori virus (strain Indian/1313/61) (Dho)
• Total number of polymer chains: 3
• Total formula weight: 161682.84

Authors

Peng, R.,Shi, Y.,Qi, J.,Gao, G.F. (deposition date: 2017-04-03, release date: 2017-10-04, Last modification date: 2024-10-23)

Primary citation

Peng, R.,Zhang, S.,Cui, Y.,Shi, Y.,Gao, G.F.,Qi, J.
Structures of human-infectingThogotovirusfusogens support a common ancestor with insect baculovirus
Proc. Natl. Acad. Sci. U.S.A., 114:E8905-E8912, 2017

PubMed Abstract: Thogotoviruses are emerging tick-borne zoonotic orthomyxoviruses infecting both humans and domestic animals with severe clinical consequences. These viruses utilize a single-envelope glycoprotein (Gp) to facilitate their entry into host cells. Here, we present the Gp structures of Thogoto and Dhori viruses, both of which are members of the genus in the family These structures, determined in the postfusion conformation, identified them as class III viral fusion proteins. It is intriguing that the Gp structures are similar to the envelope protein of baculovirus, although sharing a low sequence identity of ∼28%. Detailed structural and phylogenic analyses demonstrated that these Gps originated from a common ancestor. Among the structures, domain I is the most conserved region, particularly the fusion loops. Domain II showed the highest variability among different viruses, which might be related to their distinct host tropism. These findings increase our understanding of the divergent evolution processes of various orthomyxoviruses and indicate potential targets for developing antiviral therapeutics by intercepting virus entry.

PubMed: 29073031
DOI: 10.1073/pnas.1706125114

Experimental method

X-RAY DIFFRACTION (2.497 Å)