5XE1

Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with INCB14943

Summary for 5XE1

Entry DOI	10.2210/pdb5xe1/pdb
Descriptor	Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboxamidine (3 entities in total)
Functional Keywords	ido1, incb14943, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytosol : P14902
Total number of polymer chains	2
Total formula weight	92544.67
Authors	Xu, J.,Wu, U.,Liu, J. (deposition date: 2017-03-31, release date: 2017-05-03, Last modification date: 2023-11-22)
Primary citation	Wu, Y.,Xu, T.,Liu, J.,Ding, K.,Xu, J. Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943 Biochem. Biophys. Res. Commun., 487:339-343, 2017 Cited by PubMed: 28412361 DOI: 10.1016/j.bbrc.2017.04.061 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation