ADP-dTMP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5

Summary for 5XB3

Related5XAI 5XB2 5XB5 5XBH
DescriptorThymidylate kinase, ADENOSINE-5'-DIPHOSPHATE, THYMIDINE-5'-PHOSPHATE, ... (4 entities in total)
Functional Keywordskinase, complex, nucleotide binding, transferase
Biological sourceAquifex aeolicus (strain VF5)
Total number of polymer chains2
Total molecular weight46304.74
Biswas, A.,Jeyakanthan, J.,Sekar, K. (deposition date: 2017-03-15, release date: 2017-06-28, Last modification date: 2017-08-30)
Primary citation
Biswas, A.,Shukla, A.,Chaudhary, S.K.,Santhosh, R.,Jeyakanthan, J.,Sekar, K.
Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate
FEBS J., 284:2527-2544, 2017
PubMed: 28627020 (PDB entries with the same primary citation)
DOI: 10.1111/febs.14140
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22020.5%1.5%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution