5XAF
Crystal structure of tubulin-stathmin-TTL-Compound Z1 complex
Summary for 5XAF
Entry DOI | 10.2210/pdb5xaf/pdb |
Related | 5XAG |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (3S,4R)-4-(3-hydroxy-4-methoxyphenyl)-3-methyl-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, ... (14 entities in total) |
Functional Keywords | tubulin, structural protein |
Biological source | Bos taurus (Bovine) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 271017.74 |
Authors | |
Primary citation | Zhou, P.,Liang, Y.,Zhang, H.,Jiang, H.,Feng, K.,Xu, P.,Wang, J.,Wang, X.,Ding, K.,Luo, C.,Liu, M.,Wang, Y. Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents Eur J Med Chem, 144:817-842, 2017 Cited by PubMed: 29306206DOI: 10.1016/j.ejmech.2017.12.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.551 Å) |
Structure validation
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