5X6U

Crystal structure of human heteropentameric complex

Summary for 5X6U

Entry DOI	10.2210/pdb5x6u/pdb
Related	5X6V
Descriptor	Ragulator complex protein LAMTOR3, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR5, ... (6 entities in total)
Functional Keywords	ragulator complex, scaffold, roadblock, lysosome, mtor signaling, cell growth, protein binding
Biological source	Homo sapiens (Human) More
Cellular location	Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side : Q9UHA4 Q9Y2Q5 Cytoplasm: O43504 Lysosome : Q0VGL1 Late endosome membrane; Lipid-anchor; Cytoplasmic side: Q6IAA8
Total number of polymer chains	5
Total formula weight	61167.53
Authors	Yonehara, R.,Nada, S.,Nakai, T.,Nakai, M.,Kitamura, A.,Ogawa, A.,Nakatsumi, H.,Nakayama, K.I.,Li, S.,Standley, D.M.,Yamashita, E.,Nakagawa, A.,Okada, M. (deposition date: 2017-02-23, release date: 2017-12-06, Last modification date: 2023-11-22)
Primary citation	Yonehara, R.,Nada, S.,Nakai, T.,Nakai, M.,Kitamura, A.,Ogawa, A.,Nakatsumi, H.,Nakayama, K.I.,Li, S.,Standley, D.M.,Yamashita, E.,Nakagawa, A.,Okada, M. Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun, 8:1625-1625, 2017 Cited by PubMed: 29158492 DOI: 10.1038/s41467-017-01762-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation