5X6U
Crystal structure of human heteropentameric complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ragulator complex protein LAMTOR3 | polymer | 127 | 13868.9 | 1 | UniProt (Q9UHA4) Pfam (PF08923) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1 |
| 2 | B (B) | Ragulator complex protein LAMTOR2 | polymer | 125 | 13517.5 | 1 | UniProt (Q9Y2Q5) Pfam (PF03259) | Homo sapiens (Human) | Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3 |
| 3 | C (C) | Ragulator complex protein LAMTOR5 | polymer | 91 | 9622.9 | 1 | UniProt (O43504) Pfam (PF16672) | Homo sapiens (Human) | Hepatitis B virus X-interacting protein,HBX-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 |
| 4 | D (D) | Ragulator complex protein LAMTOR4 | polymer | 99 | 10753.2 | 1 | UniProt (Q0VGL1) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 |
| 5 | E (E) | Ragulator complex protein LAMTOR1 | polymer | 123 | 13405.1 | 1 | UniProt (Q6IAA8) Pfam (PF15454) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho |
| 6 | F, G, H, I, J (A, B, C, D, E) | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A: 2 - 124 (UniProt: Q9UHA4)
E: 42 - 161 (UniProt: Q6IAA8)
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 39 | - | expression tag |
| Ala 40 | - | expression tag |
| Ala 41 | - | expression tag |
| Asp 98 | Ser 98 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 61167.5 | |
| All* | Total formula weight | 61167.5 |
