5X0R

Crystal Structure of PXR LBD Complexed with SJB7

Summary for 5X0R

Entry DOI	10.2210/pdb5x0r/pdb
Descriptor	Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1, 4-[(4-tert-butylphenyl)sulfonyl]-1-(2,4-dimethoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole, ... (4 entities in total)
Functional Keywords	transcription
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : O75469 Q15788
Total number of polymer chains	4
Total formula weight	78888.87
Authors	Lv, L.,Lin, W.,Chai, S.C.,Zhang, Q.,Chen, T. (deposition date: 2017-01-23, release date: 2017-10-04, Last modification date: 2023-10-04)
Primary citation	Lin, W.,Wang, Y.M.,Chai, S.C.,Lv, L.,Zheng, J.,Wu, J.,Zhang, Q.,Wang, Y.D.,Griffin, P.R.,Chen, T. SPA70 is a potent antagonist of human pregnane X receptor. Nat Commun, 8:741-741, 2017 Cited by PubMed: 28963450 DOI: 10.1038/s41467-017-00780-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.665 Å)

Structure validation