5WSC

Crystal of pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, soaked with allosteric activators AMP and Glucose 6-Phosphate

Summary for 5WSC

Entry DOI	10.2210/pdb5wsc/pdb
Related	5WRP 5WS8 5WS9 5WSA 5WSB
Descriptor	Pyruvate kinase, ADENOSINE MONOPHOSPHATE, 6-O-phosphono-alpha-D-glucopyranose, ... (8 entities in total)
Functional Keywords	pyruvate kinase, glycolysis, tetramer, allostery, synergism, phospho transferase, transferase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	4
Total formula weight	207165.11
Authors	Zhong, W.,Cai, Q.,El Sahili, A.,Lescar, J.,Dedon, P.C. (deposition date: 2016-12-06, release date: 2017-11-15, Last modification date: 2023-11-08)
Primary citation	Zhong, W.,Cui, L.,Goh, B.C.,Cai, Q.,Ho, P.,Chionh, Y.H.,Yuan, M.,Sahili, A.E.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.,Lescar, J.,Dedon, P.C. Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis. Nat Commun, 8:1986-1986, 2017 Cited by PubMed: 29215013 DOI: 10.1038/s41467-017-02086-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation