5WSC
Crystal of pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, soaked with allosteric activators AMP and Glucose 6-Phosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pyruvate kinase | polymer | 475 | 51014.3 | 4 | UniProt (P9WKE5) Pfam (PF00224) Pfam (PF02887) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | PK |
| 2 | E, I, N, S (A, B, C, D) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 4 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (40467049) PubChem (40469468) PubChem (34768) PubChem (44348067) PubChem (83862) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (46875232) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (5316444) PubChem (92144436) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 3 | F, J, O, T (A, B, C, D) | 6-O-phosphono-alpha-D-glucopyranose | non-polymer | 260.1 | 4 | Chemie (G6P) | |||
| 4 | G, K, P, U (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 5 | H, L, Q, V (A, B, C, D) | OXALATE ION | non-polymer | 88.0 | 4 | Chemie (OXL) PubChem (71081) | |||
| 6 | M (B) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) PubChem (813) | |||
| 7 | R, W (C, D) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) PubChem (1061) | |||
| 8 | AA, X, Y, Z (D, A, B, C) | water | water | 18.0 | 335 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 472 (UniProt: P9WKE5)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 204057.3 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 3107.8 | |
| All* | Total formula weight | 207165.1 |
