5WNY

DNA polymerase beta substrate complex with incoming 5-FdUTP

Summary for 5WNY

DescriptorDNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... (9 entities in total)
Functional Keywordsdna ligase/dna, transferase, dna ligase-dna, transferase complex
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus P06746
Total number of polymer chains4
Total molecular weight48445.95
Authors
Schaich, M.A.,Smith, M.R.,Cloud, A.S.,Holloran, S.M.,Freudenthal, B.D. (deposition date: 2017-08-01, release date: 2017-09-13, Last modification date: 2017-11-29)
Primary citation
Schaich, M.A.,Smith, M.R.,Cloud, A.S.,Holloran, S.M.,Freudenthal, B.D.
Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues.
Chem. Res. Toxicol., 30:1993-2001, 2017
PubMed: 28862449 (PDB entries with the same primary citation)
DOI: 10.1021/acs.chemrestox.7b00173
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.236200.4%2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution