5WNG
X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR
Summary for 5WNG
Entry DOI | 10.2210/pdb5wng/pdb |
Related | 5WNE 5WNF 5WNH |
Descriptor | Rho-associated protein kinase 1, (2R)-N-(3-cyanophenyl)-2-(3-{[(6S)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamide (3 entities in total) |
Functional Keywords | rho kinase, kinase inhibitor, phosphorylation, transferase-inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 194107.71 |
Authors | |
Primary citation | Li, X.,Marshall, D.,Sibley, R.,Bosanac, T.,Ginn, J.,Kugler, S.,Gautschi, E.,Molinaro, T.,Soleymanzadeh, L.,Shih, C.K.,Young, E.R.R. Novel mechanism of Rho kinase selectivity: beyond the ATP pocket To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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