5WNG
X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Rho-associated protein kinase 1 | polymer | 415 | 48012.3 | 4 | UniProt (Q13464) Pfam (PF00069) In PDB | Homo sapiens (Human) | Renal carcinoma antigen NY-REN-35,Rho-associated,coiled-coil-containing protein kinase 1,coiled-coil-containing protein kinase I,ROCK-I,p160 ROCK-1,p160ROCK |
| 2 | A, B, C, D | (2R)-N-(3-cyanophenyl)-2-(3-{[(6S)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamide | non-polymer | 514.6 | 4 | Chemie (B4Y) | |||
| 3 | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 6 - 415 (UniProt: Q13464)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ser 2 | - | expression tag |
| Leu 3 | - | expression tag |
| His 4 | - | expression tag |
| Met 5 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 192049.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2058.6 | |
| All* | Total formula weight | 194107.7 |
