5WHK
Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M
Summary for 5WHK
Entry DOI | 10.2210/pdb5whk/pdb |
Descriptor | DX-2507 Fab heavy chain, DX-2507 Fab light chain, IgG receptor FcRn large subunit p51, ... (7 entities in total) |
Functional Keywords | neonatal receptor, fc, antibody recycling, immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P55899 Secreted . Note=(Microbial infection) In the presence of M: P61769 |
Total number of polymer chains | 4 |
Total formula weight | 92737.03 |
Authors | Edwards, T.E.,Clifton, M.C.,Nixon, A.E.,Kenniston, J.A. (deposition date: 2017-07-17, release date: 2017-09-06, Last modification date: 2023-10-04) |
Primary citation | Kenniston, J.A.,Taylor, B.M.,Conley, G.P.,Cosic, J.,Kopacz, K.J.,Lindberg, A.P.,Comeau, S.R.,Atkins, K.,Bullen, J.,TenHoor, C.,Adelman, B.A.,Sexton, D.J.,Edwards, T.E.,Nixon, A.E. Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody. J. Biol. Chem., 292:17449-17460, 2017 Cited by PubMed: 28878017DOI: 10.1074/jbc.M117.807396 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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