5WHK

Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M

5WHK の概要

• エントリーDOI: 10.2210/pdb5whk/pdb
• 分子名称: DX-2507 Fab heavy chain, DX-2507 Fab light chain, IgG receptor FcRn large subunit p51, ... (7 entities in total)
• 機能のキーワード: neonatal receptor, fc, antibody recycling, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P55899; Secreted . Note=(Microbial infection) In the presence of M: P61769
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 92737.03

構造登録者

Edwards, T.E.,Clifton, M.C.,Nixon, A.E.,Kenniston, J.A. (登録日: 2017-07-17, 公開日: 2017-09-06, 最終更新日: 2023-10-04)

• 主引用文献: Kenniston, J.A.,Taylor, B.M.,Conley, G.P.,Cosic, J.,Kopacz, K.J.,Lindberg, A.P.,Comeau, S.R.,Atkins, K.,Bullen, J.,TenHoor, C.,Adelman, B.A.,Sexton, D.J.,Edwards, T.E.,Nixon, A.E.; Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.; J. Biol. Chem., 292:17449-17460, 2017; PubMed: 28878017; DOI: 10.1074/jbc.M117.807396

実験手法

X-RAY DIFFRACTION (2.5 Å)