5WCT
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6c (SRI-29775)
Summary for 5WCT
Entry DOI | 10.2210/pdb5wct/pdb |
Related | 5W3I 5W44 5W73 5W7U 5W92 5W9G 5WA6 5WA7 5WAP 5WB3 5WCS |
Descriptor | Polymerase acidic protein, MANGANESE (II) ION, 2-{(2S)-1-[(4-chlorophenyl)acetyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid, ... (4 entities in total) |
Functional Keywords | nuclease, transcription, cap-snatching, virus, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Influenza A virus More |
Total number of polymer chains | 1 |
Total formula weight | 22457.81 |
Authors | Kumar, G.,White, S.W. (deposition date: 2017-07-01, release date: 2018-01-03, Last modification date: 2024-03-13) |
Primary citation | Beylkin, D.,Kumar, G.,Zhou, W.,Park, J.,Jeevan, T.,Lagisetti, C.,Harfoot, R.,Webby, R.J.,White, S.W.,Webb, T.R. Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Sci Rep, 7:17139-17139, 2017 Cited by PubMed: 29215062DOI: 10.1038/s41598-017-17419-6 PDB entries with the same primary citation |
Experimental method |
Structure validation
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