5WA6

Crystal structure of the influenza virus PA endonuclease in complex with an inhibitor - SRI-30007

Summary for 5WA6

Entry DOI	10.2210/pdb5wa6/pdb
Related	5W3I 5W44 5W73 5W7U 5W92 5W9G 5wa7 5wap 5wb3
Descriptor	Polymerase acidic protein, MANGANESE (II) ION, 2-{(2S)-1-[(2-fluorophenoxy)acetyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4-carboxamide, ... (4 entities in total)
Functional Keywords	virus, nuclease, transcription, cap-snatching, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Influenza A virus More
Total number of polymer chains	1
Total formula weight	23754.71
Authors	Kumar, G.,White, S.W. (deposition date: 2017-06-25, release date: 2018-05-02, Last modification date: 2024-03-13)
Primary citation	Beylkin, D.,Kumar, G.,Zhou, W.,Park, J.,Jeevan, T.,Lagisetti, C.,Harfoot, R.,Webby, R.J.,White, S.W.,Webb, T.R. Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Sci Rep, 7:17139-17139, 2017 Cited by PubMed: 29215062 DOI: 10.1038/s41598-017-17419-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation