5WCT

Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6c (SRI-29775)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Polymerase acidic protein	polymer	187	21970.2	1	UniProt (C3W5S0)	Influenza A virus
2	B, C (A)	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
3	D (A)	2-{(2S)-1-[(4-chlorophenyl)acetyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid	non-polymer		377.8	1	Chemie (GY4)
4	E (A)	water	water		18.0	16	Chemie (HOH)

Sequence modifications

A: 1 - 50 (UniProt: C3W5S0)
A: 73 - 196 (UniProt: C3W5S0)

PDB	External Database	Details
Gly 51	-	linker
Gly 52	-	linker
Ser 53	-	linker
Ala 197	-	expression tag
Ala 198	-	expression tag
Ala 199	-	expression tag
Glu 200	-	expression tag
Leu 201	-	expression tag
Ala 202	-	expression tag
Leu 203	-	expression tag
Val 204	-	expression tag
Pro 205	-	expression tag
Arg 206	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	21970.2
Non-Polymers*	Number of molecules	3
	Total formula weight	487.7
All*	Total formula weight	22457.8

*Water molecules are not included.