5WBN

Crystal structure of fragment 3-(3-Benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain

5WBN の概要

• エントリーDOI: 10.2210/pdb5wbn/pdb
• 分子名称: Histone deacetylase 6, ZINC ION, 3-(3-benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid, ... (8 entities in total)
• 機能のキーワード: histone deacetylase, hdac, hdac6, fragment screening, structural genomics consortium, sgc, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: Q9UBN7
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16264.94

構造登録者

Harding, R.J.,Walker, J.R.,Ferreira de Freitas, R.,Ravichandran, M.,Santhakumar, V.,Schapira, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H. (登録日: 2017-06-29, 公開日: 2017-08-02, 最終更新日: 2024-03-13)

• 主引用文献: Harding, R.J.,Walker, J.R.,Ferreira de Freitas, R.,Ravichandran, M.,Santhakumar, V.,Schapira, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.; Crystal structure of fragment 3-(3-Benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain; To be published,

実験手法

X-RAY DIFFRACTION (1.64 Å)