5W89
Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-18
Summary for 5W89
Entry DOI | 10.2210/pdb5w89/pdb |
Related | 5W8F |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, modified Bim BH3 peptide SAH-MS1-18, ZINC ION, ... (4 entities in total) |
Functional Keywords | stapled peptide, bcl-2 family, bh3 domain, apoptosis, peptide binding protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Membrane ; Single-pass membrane protein : Q07820 |
Total number of polymer chains | 2 |
Total formula weight | 19878.46 |
Authors | Rezaei Araghi, R.,Jenson, J.M.,Grant, R.A.,Keating, A.E. (deposition date: 2017-06-21, release date: 2018-01-17, Last modification date: 2023-11-15) |
Primary citation | Rezaei Araghi, R.,Bird, G.H.,Ryan, J.A.,Jenson, J.M.,Godes, M.,Pritz, J.R.,Grant, R.A.,Letai, A.,Walensky, L.D.,Keating, A.E. Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells. Proc. Natl. Acad. Sci. U.S.A., 115:E886-E895, 2018 Cited by PubMed: 29339518DOI: 10.1073/pnas.1712952115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.42 Å) |
Structure validation
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