5W6E

PDE1b complexed with compound 3S

Summary for 5W6E

Entry DOI	10.2210/pdb5w6e/pdb
Descriptor	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	phosphodiesterase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	42552.04
Authors	Vajdos, F.F. (deposition date: 2017-06-16, release date: 2018-05-30, Last modification date: 2024-03-13)
Primary citation	Humphrey, J.M.,Movsesian, M.,Am Ende, C.W.,Becker, S.L.,Chappie, T.A.,Jenkinson, S.,Liras, J.L.,Liras, S.,Orozco, C.,Pandit, J.,Vajdos, F.F.,Vandeput, F.,Yang, E.,Menniti, F.S. Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1. J. Med. Chem., 61:4635-4640, 2018 Cited by PubMed: 29718668 DOI: 10.1021/acs.jmedchem.8b00374 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation