5W49
The crystal structure of human S-adenosylhomocysteine hydrolase (AHCY) bound to oxadiazole inhibitor
Summary for 5W49
Entry DOI | 10.2210/pdb5w49/pdb |
Related | 5W4B |
Descriptor | Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P23526 |
Total number of polymer chains | 2 |
Total formula weight | 97863.85 |
Authors | Dougan, D.R.,Lawson, J.D.,Lane, W. (deposition date: 2017-06-09, release date: 2017-06-28, Last modification date: 2024-03-13) |
Primary citation | Uchiyama, N.,Dougan, D.R.,Lawson, J.D.,Kimura, H.,Matsumoto, S.I.,Tanaka, Y.,Kawamoto, T. Identification of AHCY inhibitors using novel high-throughput mass spectrometry. Biochem. Biophys. Res. Commun., 491:1-7, 2017 Cited by PubMed: 28533090DOI: 10.1016/j.bbrc.2017.05.107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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