Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004013 | molecular_function | adenosylhomocysteinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0033353 | biological_process | S-adenosylmethionine cycle |
| A | 0042470 | cellular_component | melanosome |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0004013 | molecular_function | adenosylhomocysteinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0033353 | biological_process | S-adenosylmethionine cycle |
| B | 0042470 | cellular_component | melanosome |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | binding site for residue NAD A 501 |
| Chain | Residue |
| A | ASP190 |
| A | ASN248 |
| A | THR275 |
| A | THR276 |
| A | GLY277 |
| A | CYS278 |
| A | ILE281 |
| A | ILE299 |
| A | GLY300 |
| A | ASN346 |
| A | HOH649 |
| A | ASN191 |
| A | HOH650 |
| A | HOH652 |
| A | HOH671 |
| B | GLN413 |
| B | LYS426 |
| B | TYR430 |
| A | GLY222 |
| A | ASP223 |
| A | VAL224 |
| A | THR242 |
| A | GLU243 |
| A | ILE244 |
| A | ASP245 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | ARG205 |
| A | LYS322 |
| A | PRO323 |
| A | CYS349 |
| A | HOH620 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | MET210 |
| A | ALA212 |
| A | LYS214 |
| B | PHE356 |
| B | LYS401 |
| B | LEU402 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | GLY284 |
| A | ARG285 |
| A | ASP307 |
| A | TRP310 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | PHE356 |
| A | LYS401 |
| A | HOH626 |
| B | MET210 |
| B | ALA212 |
| B | LYS214 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | VAL161 |
| A | ASN181 |
| A | ASP182 |
| B | HIS429 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 507 |
| Chain | Residue |
| A | ASN320 |
| A | GLN324 |
| A | ASP326 |
| A | GLU341 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue 9W1 A 508 |
| Chain | Residue |
| A | HIS55 |
| A | THR57 |
| A | GLU59 |
| A | THR60 |
| A | SER83 |
| A | GLN85 |
| A | LEU347 |
| A | ALA350 |
| A | MET351 |
| A | HIS353 |
| A | MET358 |
| A | PHE362 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 509 |
| Chain | Residue |
| A | GLY213 |
| A | VAL215 |
| A | ARG238 |
| A | TYR257 |
| B | LEU402 |
| site_id | AD1 |
| Number of Residues | 31 |
| Details | binding site for residue NAD B 501 |
| Chain | Residue |
| B | HOH725 |
| B | HOH741 |
| B | HOH744 |
| A | LEU409 |
| A | GLN413 |
| A | LYS426 |
| A | TYR430 |
| B | ASP190 |
| B | ASN191 |
| B | GLY222 |
| B | ASP223 |
| B | VAL224 |
| B | THR242 |
| B | GLU243 |
| B | ILE244 |
| B | ASP245 |
| B | ASN248 |
| B | THR275 |
| B | THR276 |
| B | GLY277 |
| B | CYS278 |
| B | ILE281 |
| B | ILE299 |
| B | GLY300 |
| B | HIS301 |
| B | ASN346 |
| B | 9W1509 |
| B | HOH616 |
| B | HOH651 |
| B | HOH660 |
| B | HOH661 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| B | LEU283 |
| B | GLY284 |
| B | ARG285 |
| B | ASP307 |
| B | TRP310 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| A | LEU402 |
| A | ASN403 |
| B | GLY213 |
| B | VAL215 |
| B | ARG238 |
| B | ALA253 |
| B | TYR257 |
| B | GLU258 |
| B | HOH617 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | GLU317 |
| B | VAL319 |
| B | ARG327 |
| B | ARG329 |
| B | HOH606 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| A | THR207 |
| A | ASP208 |
| A | VAL209 |
| B | GLU28 |
| B | SER355 |
| B | HOH608 |
| B | HOH624 |
| B | HOH672 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| B | TRP17 |
| B | LYS20 |
| B | VAL316 |
| B | GLU317 |
| B | ARG329 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| A | HIS429 |
| B | VAL161 |
| B | ASN181 |
| B | ASP182 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| B | ARG205 |
| B | LYS322 |
| B | PRO323 |
| B | CYS349 |
| site_id | AD9 |
| Number of Residues | 13 |
| Details | binding site for residue 9W1 B 509 |
| Chain | Residue |
| B | HIS55 |
| B | THR57 |
| B | GLU59 |
| B | THR60 |
| B | SER83 |
| B | GLN85 |
| B | LEU347 |
| B | ALA350 |
| B | MET351 |
| B | HIS353 |
| B | MET358 |
| B | PHE362 |
| B | NAD501 |
Functional Information from PROSITE/UniProt
| site_id | PS00738 |
| Number of Residues | 15 |
| Details | ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. SCNiFSTQDhAAAAI |
| Chain | Residue | Details |
| A | SER78-ILE92 | |
| site_id | PS00739 |
| Number of Residues | 17 |
| Details | ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKvavVaGYGdVGKGc.A |
| Chain | Residue | Details |
| A | GLY213-ALA229 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P10760","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12590576","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9586999","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"29192674","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P50247","evidenceCode":"ECO:0000250"}]} |
