Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004013 | molecular_function | adenosylhomocysteinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0033353 | biological_process | S-adenosylmethionine cycle |
A | 0042470 | cellular_component | melanosome |
A | 0070062 | cellular_component | extracellular exosome |
B | 0004013 | molecular_function | adenosylhomocysteinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005829 | cellular_component | cytosol |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016787 | molecular_function | hydrolase activity |
B | 0033353 | biological_process | S-adenosylmethionine cycle |
B | 0042470 | cellular_component | melanosome |
B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | binding site for residue NAD A 501 |
Chain | Residue |
A | ASP190 |
A | ASN248 |
A | THR275 |
A | THR276 |
A | GLY277 |
A | CYS278 |
A | ILE281 |
A | ILE299 |
A | GLY300 |
A | ASN346 |
A | HOH649 |
A | ASN191 |
A | HOH650 |
A | HOH652 |
A | HOH671 |
B | GLN413 |
B | LYS426 |
B | TYR430 |
A | GLY222 |
A | ASP223 |
A | VAL224 |
A | THR242 |
A | GLU243 |
A | ILE244 |
A | ASP245 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue EDO A 502 |
Chain | Residue |
A | ARG205 |
A | LYS322 |
A | PRO323 |
A | CYS349 |
A | HOH620 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue EDO A 503 |
Chain | Residue |
A | MET210 |
A | ALA212 |
A | LYS214 |
B | PHE356 |
B | LYS401 |
B | LEU402 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue EDO A 504 |
Chain | Residue |
A | GLY284 |
A | ARG285 |
A | ASP307 |
A | TRP310 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue EDO A 505 |
Chain | Residue |
A | PHE356 |
A | LYS401 |
A | HOH626 |
B | MET210 |
B | ALA212 |
B | LYS214 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue EDO A 506 |
Chain | Residue |
A | VAL161 |
A | ASN181 |
A | ASP182 |
B | HIS429 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue EDO A 507 |
Chain | Residue |
A | ASN320 |
A | GLN324 |
A | ASP326 |
A | GLU341 |
site_id | AC8 |
Number of Residues | 12 |
Details | binding site for residue 9W1 A 508 |
Chain | Residue |
A | HIS55 |
A | THR57 |
A | GLU59 |
A | THR60 |
A | SER83 |
A | GLN85 |
A | LEU347 |
A | ALA350 |
A | MET351 |
A | HIS353 |
A | MET358 |
A | PHE362 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue EDO A 509 |
Chain | Residue |
A | GLY213 |
A | VAL215 |
A | ARG238 |
A | TYR257 |
B | LEU402 |
site_id | AD1 |
Number of Residues | 31 |
Details | binding site for residue NAD B 501 |
Chain | Residue |
B | HOH725 |
B | HOH741 |
B | HOH744 |
A | LEU409 |
A | GLN413 |
A | LYS426 |
A | TYR430 |
B | ASP190 |
B | ASN191 |
B | GLY222 |
B | ASP223 |
B | VAL224 |
B | THR242 |
B | GLU243 |
B | ILE244 |
B | ASP245 |
B | ASN248 |
B | THR275 |
B | THR276 |
B | GLY277 |
B | CYS278 |
B | ILE281 |
B | ILE299 |
B | GLY300 |
B | HIS301 |
B | ASN346 |
B | 9W1509 |
B | HOH616 |
B | HOH651 |
B | HOH660 |
B | HOH661 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue EDO B 502 |
Chain | Residue |
B | LEU283 |
B | GLY284 |
B | ARG285 |
B | ASP307 |
B | TRP310 |
site_id | AD3 |
Number of Residues | 9 |
Details | binding site for residue EDO B 503 |
Chain | Residue |
A | LEU402 |
A | ASN403 |
B | GLY213 |
B | VAL215 |
B | ARG238 |
B | ALA253 |
B | TYR257 |
B | GLU258 |
B | HOH617 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue EDO B 504 |
Chain | Residue |
B | GLU317 |
B | VAL319 |
B | ARG327 |
B | ARG329 |
B | HOH606 |
site_id | AD5 |
Number of Residues | 8 |
Details | binding site for residue EDO B 505 |
Chain | Residue |
A | THR207 |
A | ASP208 |
A | VAL209 |
B | GLU28 |
B | SER355 |
B | HOH608 |
B | HOH624 |
B | HOH672 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue EDO B 506 |
Chain | Residue |
B | TRP17 |
B | LYS20 |
B | VAL316 |
B | GLU317 |
B | ARG329 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue EDO B 507 |
Chain | Residue |
A | HIS429 |
B | VAL161 |
B | ASN181 |
B | ASP182 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue EDO B 508 |
Chain | Residue |
B | ARG205 |
B | LYS322 |
B | PRO323 |
B | CYS349 |
site_id | AD9 |
Number of Residues | 13 |
Details | binding site for residue 9W1 B 509 |
Chain | Residue |
B | HIS55 |
B | THR57 |
B | GLU59 |
B | THR60 |
B | SER83 |
B | GLN85 |
B | LEU347 |
B | ALA350 |
B | MET351 |
B | HIS353 |
B | MET358 |
B | PHE362 |
B | NAD501 |
Functional Information from PROSITE/UniProt
site_id | PS00738 |
Number of Residues | 15 |
Details | ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. SCNiFSTQDhAAAAI |
Chain | Residue | Details |
A | SER78-ILE92 | |
site_id | PS00739 |
Number of Residues | 17 |
Details | ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKvavVaGYGdVGKGc.A |
Chain | Residue | Details |
A | GLY213-ALA229 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | THR57 | |
B | ASP190 | |
A | ASP131 | |
A | GLU156 | |
A | LYS186 | |
A | ASP190 | |
B | THR57 | |
B | ASP131 | |
B | GLU156 | |
B | LYS186 | |
Chain | Residue | Details |
A | THR157 | |
B | GLU243 | |
B | ASN248 | |
B | ILE299 | |
B | ASN346 | |
B | HIS353 | |
A | GLY222 | |
A | GLU243 | |
A | ASN248 | |
A | ILE299 | |
A | ASN346 | |
A | HIS353 | |
B | THR157 | |
B | GLY222 | |
Chain | Residue | Details |
A | SER183 | |
B | SER183 | |
Chain | Residue | Details |
A | LYS186 | |
B | LYS186 | |
Chain | Residue | Details |
A | TYR193 | |
B | TYR193 | |