5W2O

Crystal structure of Mycobacterium tuberculosis KasA

Summary for 5W2O

• Entry DOI: 10.2210/pdb5w2o/pdb
• Related: 2WGD 2WGE 2WGF 2WGG 4C6U 4C6V 4C6W 4C6X 4C6Z 4C70 4C71 4C72 4C73 5LD8
• Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 1, SODIUM ION, GLYCEROL, ... (7 entities in total)
• Functional Keywords: beta ketoacyl synthase i, lipid synthesis, fatty acid biosynthesis, transferase
• Biological source: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
• Total number of polymer chains: 1
• Total formula weight: 46645.92

Authors

Capodagli, G.C.,Neiditch, M.B. (deposition date: 2017-06-06, release date: 2018-12-05, Last modification date: 2023-10-04)

• Primary citation: Kumar, P.,Capodagli, G.C.,Awasthi, D.,Shrestha, R.,Maharaja, K.,Sukheja, P.,Li, S.G.,Inoyama, D.,Zimmerman, M.,Ho Liang, H.P.,Sarathy, J.,Mina, M.,Rasic, G.,Russo, R.,Perryman, A.L.,Richmann, T.,Gupta, A.,Singleton, E.,Verma, S.,Husain, S.,Soteropoulos, P.,Wang, Z.,Morris, R.,Porter, G.,Agnihotri, G.,Salgame, P.,Ekins, S.,Rhee, K.Y.,Connell, N.,Dartois, V.,Neiditch, M.B.,Freundlich, J.S.,Alland, D.; Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA.; MBio, 9:-, 2018; PubMed: 30563908; DOI: 10.1128/mBio.02101-17

Experimental method

X-RAY DIFFRACTION (1.8 Å)