4C6U
Crystal structure of M. tuberculosis KasA in complex with TLM5
Summary for 4C6U
Entry DOI | 10.2210/pdb4c6u/pdb |
Related | 4C6V 4C6W 4C6X 4C6Z 4C70 4C71 4C72 4C73 |
Descriptor | 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, 1,2-ETHANEDIOL, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | transferase, kas enzyme, type 2 fatty acid biosynthesis, mycolic acid synthesis, thiolactomycin |
Biological source | MYCOBACTERIUM TUBERCULOSIS |
Total number of polymer chains | 1 |
Total formula weight | 46319.75 |
Authors | Schiebel, J.,Kapilashrami, K.,Fekete, A.,Bommineni, G.R.,Schaefer, C.M.,Mueller, M.J.,Tonge, P.J.,Kisker, C. (deposition date: 2013-09-19, release date: 2013-10-09, Last modification date: 2023-12-20) |
Primary citation | Schiebel, J.,Kapilashrami, K.,Fekete, A.,Bommineni, G.R.,Schaefer, C.M.,Mueller, M.J.,Tonge, P.J.,Kisker, C. Structural Basis for the Recognition of Mycolic Acid Precursors by Kasa, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis J.Biol.Chem., 288:34190-, 2013 Cited by PubMed: 24108128DOI: 10.1074/JBC.M113.511436 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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