5W2C
Structure of human DNA polymerase kappa in complex with Lucidin-derived DNA adduct and incoming dAMPNPP
Summary for 5W2C
Entry DOI | 10.2210/pdb5w2c/pdb |
Related | 5W2A |
Descriptor | DNA polymerase kappa, DNA (5'-D(P*CP*GP*GP*AP*TP*CP*GP*AP*C)-3'), DNA (5'-D(*CP*TP*AP*TP*(LDG)P*TP*CP*GP*AP*TP*CP*CP*G)-3'), ... (9 entities in total) |
Functional Keywords | translesion synthesis, lucidin-derived dna adduct, dna polymerase kappa, mutagenesis, replication |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q9UBT6 |
Total number of polymer chains | 6 |
Total formula weight | 142148.26 |
Authors | |
Primary citation | Yockey, O.P.,Jha, V.,Ghodke, P.P.,Xu, T.,Xu, W.,Ling, H.,Pradeepkumar, P.I.,Zhao, L. Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase kappa. Chem. Res. Toxicol., 30:2023-2032, 2017 Cited by PubMed: 28972744DOI: 10.1021/acs.chemrestox.7b00227 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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