5W21

Crystal Structure of a 1:1:1 FGF23-FGFR1c-aKlotho Ternary Complex

Summary for 5W21

• Entry DOI: 10.2210/pdb5w21/pdb
• Descriptor: Klotho, Fibroblast growth factor 23, Fibroblast growth factor receptor 1, ... (6 entities in total)
• Functional Keywords: complex, ligand, receptor, co-receptor, hydrolase-protein binding complex, hydrolase/protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 165062.43

Authors

Mohammadi, M. (deposition date: 2017-06-05, release date: 2018-01-24, Last modification date: 2023-10-04)

• Primary citation: Chen, G.,Liu, Y.,Goetz, R.,Fu, L.,Jayaraman, S.,Hu, M.C.,Moe, O.W.,Liang, G.,Li, X.,Mohammadi, M.; alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.; Nature, 553:461-466, 2018; PubMed: 29342138; DOI: 10.1038/nature25451

Experimental method

X-RAY DIFFRACTION (3 Å)