5VYF
Structure of single chain Fel d 1 bound to a neutralizing antibody
Summary for 5VYF
Entry DOI | 10.2210/pdb5vyf/pdb |
Descriptor | Antibody light chain, Antibody Fab heavy chain, Chimera of Major allergen I polypeptide chain 2,Major allergen I polypeptide chain 1, ... (5 entities in total) |
Functional Keywords | antibody, allergen, therapeutic, immune system |
Biological source | Mus musculus More |
Total number of polymer chains | 6 |
Total formula weight | 137666.32 |
Authors | Franklin, M.C. (deposition date: 2017-05-25, release date: 2018-04-04, Last modification date: 2024-10-09) |
Primary citation | Orengo, J.M.,Radin, A.R.,Kamat, V.,Badithe, A.,Ben, L.H.,Bennett, B.L.,Zhong, S.,Birchard, D.,Limnander, A.,Rafique, A.,Bautista, J.,Kostic, A.,Newell, D.,Duan, X.,Franklin, M.C.,Olson, W.,Huang, T.,Gandhi, N.A.,Lipsich, L.,Stahl, N.,Papadopoulos, N.J.,Murphy, A.J.,Yancopoulos, G.D. Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement. Nat Commun, 9:1421-1421, 2018 Cited by PubMed: 29650949DOI: 10.1038/s41467-018-03636-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
Download full validation report