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5VYF

Structure of single chain Fel d 1 bound to a neutralizing antibody

Summary for 5VYF
Entry DOI10.2210/pdb5vyf/pdb
DescriptorAntibody light chain, Antibody Fab heavy chain, Chimera of Major allergen I polypeptide chain 2,Major allergen I polypeptide chain 1, ... (5 entities in total)
Functional Keywordsantibody, allergen, therapeutic, immune system
Biological sourceMus musculus
More
Total number of polymer chains6
Total formula weight137666.32
Authors
Franklin, M.C. (deposition date: 2017-05-25, release date: 2018-04-04, Last modification date: 2023-10-04)
Primary citationOrengo, J.M.,Radin, A.R.,Kamat, V.,Badithe, A.,Ben, L.H.,Bennett, B.L.,Zhong, S.,Birchard, D.,Limnander, A.,Rafique, A.,Bautista, J.,Kostic, A.,Newell, D.,Duan, X.,Franklin, M.C.,Olson, W.,Huang, T.,Gandhi, N.A.,Lipsich, L.,Stahl, N.,Papadopoulos, N.J.,Murphy, A.J.,Yancopoulos, G.D.
Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement.
Nat Commun, 9:1421-1421, 2018
Cited by
PubMed: 29650949
DOI: 10.1038/s41467-018-03636-8
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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