5VWQ
E.coli Aspartate aminotransferase-(1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP)
Summary for 5VWQ
| Entry DOI | 10.2210/pdb5vwq/pdb |
| Related | 5VWO 5VWR |
| Descriptor | Aspartate aminotransferase, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE (3 entities in total) |
| Functional Keywords | aspartate aminotransferase, pmp, mechanism-based inactivator, (1r, 3s, 4s)-3-amino-4-fluorocyclopentane-1-carboxylic acid (fcp), transferase |
| Biological source | Escherichia coli K-12 |
| Cellular location | Cytoplasm: P00509 |
| Total number of polymer chains | 4 |
| Total formula weight | 175469.55 |
| Authors | Mascarenhas, R.,Lehrer, H.,Liu, D.,Ringe, D. (deposition date: 2017-05-22, release date: 2017-08-30, Last modification date: 2023-11-29) |
| Primary citation | Mascarenhas, R.,Le, H.V.,Clevenger, K.D.,Lehrer, H.J.,Ringe, D.,Kelleher, N.L.,Silverman, R.B.,Liu, D. Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry, 56:4951-4961, 2017 Cited by PubMed: 28816437DOI: 10.1021/acs.biochem.7b00499 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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