5VVD

Structure of human endothelial nitric oxide synthase heme domain in complex with 4-(2-(((2-Amino-4-methylquinolin-7-yl)methyl)amino)ethyl)benzonitrile

5VVD の概要

• エントリーDOI: 10.2210/pdb5vvd/pdb
• 関連するPDBエントリー: 5VUV 5VUW 5VUX 5VUY 5VUZ 5VV0 5VV1 5VV2 5VV3 5VV4 5VV5 5VVB 5VVC
• 分子名称: Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (10 entities in total)
• 機能のキーワード: nitric oxide synthase inhibitor complex, heme enzyme, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 205467.07

構造登録者

Li, H.,Poulos, T.L. (登録日: 2017-05-19, 公開日: 2017-08-16, 最終更新日: 2023-10-04)

• 主引用文献: Pensa, A.V.,Cinelli, M.A.,Li, H.,Chreifi, G.,Mukherjee, P.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.; Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.; J. Med. Chem., 60:7146-7165, 2017; PubMed: 28776992; DOI: 10.1021/acs.jmedchem.7b00835

実験手法

X-RAY DIFFRACTION (2.25 Å)